In this lesson, we will explore the topic of sensation as you learn about the sensations of touch, pressure, temperature, and pain. You will discover the differences between free nerve endings, Merkel disks, Meissner corpuscles, root hair plexuses, and Pacinian corpuscles. We will also talk about sensory adaptation and referred pain. You will learn where in the brain messages from sensory receptors end up. We will end the lesson by discussing three disorders of cutaneous sensation—tactile defensiveness, congenital insensitivity to pain, and peripheral neuropathy.